Fast, selective and reliable extraction technique namely Supercritical Carbon Dioxide Extraction (SC-CO2) has been proposed in this study. Experiments were carried out to determine the optimum conditions for pressure and temperature of SC-CO2 extraction for Curcuma longa L. using response surface methodology (RSM) based on central composite design (CCD) with the aim to obtain the highest percentage of yield and curcuminoid concentration. At a pressure of 4807 psi and temperature of 90°C, extraction of turmeric rhizome using SC-CO2 extraction resulted in oil yield of 7.54% (dry weight basis) and curcuminoid concentration of 0.023 mg 100-1g of dry turmeric rhizome. From the study, it can be concluded that the percentage yield an