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Cytotoxic activity of Luvunga Scandens against human cancer cell lines
Putri Nur Hidayah Al-Zikri1, Muhammad Taher2, Deny Susanti3, Ichwan, Solachuddin Jauhari Arief4.
Luvunga scandens belongs to the family of Rutaceae which usually inhabit tropical
and moist environment. This plant is known as ‘Mengkurat Jakun’ among locals and
used traditionally to treat fever and fatigue via decoction. The aim of this study was to
investigate the cytotoxic activity of the leaves and stems extracts of L. scandens
extract. Extracts of the leaves and stems were obtained from sequential extraction
procedures by various organic solvents. All extracts were subjected to cytotoxic study
by 3-(4, 5-dimethylthaizol-2-yl)-2, 5-diphenyltetrazolium bromide (MTT) assay. In in vitro
cytotoxicity assay, all L. scandens extracts exhibited cytotoxicity against human
breast adenocarcinoma (MCF-7) and human lung adenocarcinoma (A549) cell lines.
The IC50 values of dichloromethane and methanol extracts from the leaves of L.
scandens against MCF-7 cell line were 62.5 µg/mL and 88.0 µg/mL, respectively,
whereas IC50 of methanol extract from stem was 81.0 µg/mL. All extracts were less
active against A549 cell line where IC50 value were not be determined. The present
findings revealed the potential of L. scandens as a cytotoxic agent against MCF-7 cell
line. However, further studies should be planned to evaluate role of the plant in
cytotoxic activity.
Affiliation:
- International Islamic University Malaysia, Malaysia
- International Islamic University Malaysia, Malaysia
- International Islamic University Malaysia, Malaysia
- International Islamic University Malaysia, Malaysia
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Indexation |
Indexed by |
MyJurnal (2021) |
H-Index
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6 |
Immediacy Index
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0.000 |
Rank |
0 |
Indexed by |
Scopus 2020 |
Impact Factor
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CiteScore (1.4) |
Rank |
Q3 (Engineering (all)) |
Additional Information |
SJR (0.191) |
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